Library / Immunopathogenesis of vitiligo

Autoimmunity Reviews
Volume 10, Issue 12, October 2011, Pages 762-765

Manuel Sandoval-Cruza, b, Mario García-Carrascoc, d, Corresponding Author Contact Information, E-mail The Corresponding Author, Renán Sánchez-Porrasd, Claudia Mendoza-Pintod, Mario Jiménez-Hernándezd, Pamela Munguía-Realpozod, Alejandro Ruiz-Argüellese
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a Department of Dermatology, HGR 36, IMSS, Puebla, Mexico
b Department of Internal Medicine, HGR 36, CMN Manuel Avila Camacho, IMSS, Puebla, Mexico
c Department of Immunology and Rheumatology, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico
d Systemic Autoimmune Disease Research Unit, HGR 36, IMSS, Puebla, Mexico
e Laboratorios Clinicos de Puebla, Puebla, Mexico

Received 1 February 2011; Accepted 10 February 2011. Available online 18 February 2011.
Abstract

previous termVitiligonext term is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of previous termvitiligonext term. Cellular and humoral immunities have been implicated in the development of previous termvitiligonext term and their role continues to be investigated. Peripheral blood and skin biopsies of patients with previous termvitiligonext term show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of previous termvitiligo or only a consequence.

http://www.sciencedirect.com/science/article/pii/S1568997211000309

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