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>3% *from 1 to 8% depending on region prevalence
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Biochemistry

Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Dec 06

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The non-profit VR Foundation accepts a variety of contributed material on vitiligo, melanoma and pigmentary disorders for possible inclusion on the website www.Vitinomics.net....

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 29

Study of total antioxidants status in Indian vitiligo patients

Suman Singh1, Usha Singh1, Shyam Sunder Pandey2

Egyptian Dermatology Online Journal 7 (1): 2 1Division of Immunopathology, Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005,...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

The Importance of L-Phenylalanine Transport and Its Autocrine Turnover to L-Tyrosine for Melanogenesis in Human Epidermal Melanocytes

K. U. Schallreuter*,†,1 and J. M. Wood* *Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, Bradford, United Kingdom; and †Institute for Pigmentary Disorders e. V. in association with the Ernst-Moritz-Arndt University Greifswald Biotechnikum, Walter-Rathenau-Strasse 49a, 17489 Greifswald, Germany Received June 27, 1999

Biochem Biophys Res Commun. 1999 Aug 27;262(2):423-8. Abstract A comparative study of (14)C-labeled l-phenylalanine and (3)H-labeled L-tyrosine uptake in cultures of human...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Study on the Antioxidant Status of Vitiligo Patients of Different Age Groupsin Baroda

Agrawal D, Shajil EM, Marfatia YS, Begum R. Source Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Vadodara, Gujarat, India.

Pigment Cell Res. 2004 Jun;17(3):289-94. http://www.ncbi.nlm.nih.gov/pubmed/15140075 Abstract One of the major hypotheses in the pathogenesis of vitiligo is the oxidative...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Perturbed 6-Tetrahydrobiopterin Recycling via Decreased Dihydropteridine Reductase in Vitiligo: More Evidence for H2O2 Stress

Sybille Hasse,_ Nicholas C.J. Gibbons,_ Hartmut Rokos,_ Lee K. Marles,_ and Karin U. Schallreuter_w _Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK; wInstitute for Pigmentary Disorders in Association with the Ernst-Moritz-Arndt University of Greifswald, Greifswald, Germany

J Invest Dermatol 122:307 –313, 2004 To date there is ample evidence that patients with vitiligo accumulate millimolar concentrations of hydrogen peroxide (H2O2) in their...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Oxidative Stress and Human Genetic Variation

Ralf Morgenstern3 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden SE-171 77

J. Nutr. November 1, 2004 vol. 134 no. 11 3173S-3174S EXPANDED ABSTRACT Genetic variants, largely in the form of single nucleotide polymorphisms (SNPs) are found in almost...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Keratinocyte Growth Factor Promotes Melanosome Transfer to Keratinocytes

Giorgia Cardinali,_ Simona Ceccarelli,wz Daniela Kovacs,_ Nicaela Aspite,_ Lavinia Vittoria Lotti,w Maria Rosaria Torrisi,_wz and Mauro Picardo_

_Iistituto Dermatologico San Gallicano, IRCSS, wDipartimento di Medicina Sperimentale e Patologia, and zAzienda Ospedaliera Sant’Andrea, Universita` di Roma ‘‘La Sapienza,’’...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Hair Follicle Pigmentation

Andrzej Slominski, Jacobo Wortsman, Przemyslaw M Plonka, Karin U Schallreuter,, Ralf Paus and Desmond J Tobin

Journal of Investigative Dermatology (2005) 124, 13–21; doi:10.1111/j.0022-202X.2004.23528.x http://www.nature.com/jid/journal/v124/n1/full/5602636a.html Abstract Hair shaft...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Decreased phenylalanine uptake and turnover in patients with vitiligo.

Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM. Source Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, UK. K.Schallreuter@bradford.ac.uk

Mol Genet Metab. 2005 Dec;86 Suppl 1:S27-33. Epub 2005 Sep 6. Abstract The human epidermis has the full machinery for autocrine L-phenylalanine turnover to L-tyrosine in...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: More evidence for oxidative stress in vitiligo

Karin U. Schallreuter a,b,c,*, Nicholas C.J. Gibbons a,b,c, Carsten Zothner a,b,c, Souna M. Elwary a, Hartmut Rokos a,b,c, John M. Wood a a Clinical and Experimental Dermatology/Department of Biomedical Sciences, University of Bradford, Bradford BD7 1DP, UK b Institute for Pigmentary Disorders in Association with E M Arndt University Greifswald, Germany c University of Bradford, UK Received 9 August 2006 Available online 31 August 2006

The human epidermis holds the capacity for autocrine cholinergic signal transduction, but the presence of butyrylcholinesterase (BchE) has not been shown so far. Our results...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Associations between Catalase Phenotype and Genotype: Modification by Epidemiologic Factors

Jiyoung Ahn,1,6 Susan Nowell,3 Susan E. McCann,1 Jihnhee Yu,2 Lisa Carter,1 Nicholas P. Lang,3,4 Fred F. Kadlubar,5 Luke D. Ratnasinghe,5 and Christine B. Ambrosone1 1Department of Epidemiology, Roswell Park Cancer Institute; 2Department of Biostatistics, State University of New York at Buffalo, Buffalo, New York; 3University of Arkansas for Medical Sciences; 4Central Arkansas Veterans Healthcare System, Little Rock, Arkansas; 5Division of Pharmacogenomics and Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arkansas; and 6Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NZH, Bethesda, Maryland

Abstract Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. A _262C ! T polymorphism in the promoter region...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

A Role for Tyrosinase-Related Protein 1 in 4-tert- Butylphenol-Induced Toxicity in Melanocytes Implications for Vitiligo

Prashiela Manga, David Sheyn, Fan Yang, Rangaprasad Sarangarajan, and Raymond E. Boissy From the Department of Dermatology, University of Cincinnati, Cincinnati, Ohio

Am J Pathol 2006, 169:1652–1662 Vitiligo presents with depigmented cutaneous lesions following localized melanocyte death. Multiple factors contribute to cell death, including...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

Angel L. Pey,* Aurora Martinez,* Ramamurthy Charubala,† Derek J. Maitland,‡ Knut Teigen,* Ana Calvo,* Wolfgang Pfleiderer,† John M. Wood,§ and Karin U. Schallreuter§,1 *Department of Biomedicine, University of Bergen, Bergen, Norway; †Fachbereich Chemie, University of Konstanz, Konstanz, Germany; and Departments of ‡Chemical and Forensic Sciences, §Clinical and Experimental Dermatology/Department of Biomedical Sciences, University of Bradford, Bradford, UK

FASEB J. 20, E1451–E1464 ABSTRACT Pterin-4a-carbinolamine dehydratase (PCD) is an essential component of the phenylalanine hydroxylase (PAH) system, catalyzing the regeneration...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Psysiological factors that regulate skin pigmentation

Yuji Yamaguchi1,2* and Vincent J. Hearing2 1Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan 2Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 2, March/April 2009, Pages 193–199 _ E-mail: yujin@med.nagoya-cu.ac.jp Abstract. More...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Oxidative stress in the blood of patients with active localized vitiligo

Objectives: Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

On the Etiology of Contact/Occupational Vitiligo

RAYMOND E. BOISSY andPRASHIELA MANGA Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0592, USA *Address reprint requests to Prof. Raymond E. Boissy, Department of Dermatology, University of Cincinnati College of Medicine Cincinnati, OH 45267-0592, USA. E-mail: boissyre@ucmail.uc.edu Received 7 November 2003; in final form 23 December 2003

Vitiligo is an acquired depigmentary disorder of the skin that results from the selective destruction of melanocytes, generally during the second decade of life and affecting...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Membrane Lipid Alterations as a Possible Basis for Melanocyte Degeneration in Vitiligo

Maria Lucia Dell’Anna, Monica Ottaviani, Veronica Albanesi, Andrea Paro Vidolin, Giovanni Leone, Carmela Ferraro, Andrea Cossarizza, Luisa Rossi5 and Mauro Picardo

Journal of Investigative Dermatology (2007) 127, 1226–1233. doi:10.1038/sj.jid.5700700; published online 18 January 2007 The occurrence of oxidative stress has been proposed...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Impaired PI3K/Akt Activation-Mediated NF-jB Inactivation Under Elevated TNF-a Is More Vulnerable to Apoptosis in Vitiliginous Keratinocytes

Nan-Hyung Kim2, Songhee Jeon, Hyun-Joo Lee and Ai-Young Lee

Levels of the cytokines IL-6, IL-1a, and tumor necrosis factor-a (TNF-a) are significantly higher in lesional than innon-lesional skin of patients with vitiligo. However, how...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Estrogens Can Contribute to Hydrogen Peroxide Generation and Quinone-Mediated DNA Damage in Peripheral Blood Lymphocytes from Patientswith Vitiligo

Karin U. Schallreuter, Georgia Chiuchiarelli, Eduardo Cemeli, Souna M. Elwary, Johanna M. Gillbro,Jennifer D. Spencer, Hartmut Rokos, Angela Panske, Bhaven Chavan, John M. Wood and Diana Anderson

Journal of Investigative Dermatology (2006) 126, 1036–1042. doi:10.1038/sj.jid.5700257; published online 9 March 2006 To date there is ample in vivo and in vitro evidence for...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)

Andreya. Sharov,_ Desmond J. Tobin,w Tatyana Y. Sharova,_ Ruzanna Atoyan,_ and Vladimir A. Botchkarev_ _Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA; wDepartment of Biomedical Sciences, University of Bradford, Bradford, UK

Melanin synthesis in the hair follicle (HF) is strictly coupled to the growth stage of the hair cycle and is interrupted during follicle regression (catagen) and resting. Using...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Beta Adrenergic Receptors in Keratinocytes

Raja K. Sivamania,*, Susanne T. Lama,*, and R. Rivkah Isseroffb aMedical Student, Department of Dermatology, University of California, Davis, CA 95616 bProfessor of Dermatology, Department of Dermatology, University of California, Davis, CA 95616 and Dermatology Service, Department of Veterans Affairs, Northern California Health Care System, Mather, CA 95655

Synopsis Beta2 adrenergic receptors were identified in keratinocytes more than 30 years ago, but their function in the epidermis continues to be elucidated. Abnormalities in...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance

Sergei A. Grando1, Mark R. Pittelkow2 and Karin U. Schallreuter3

J Invest Dermatol. 2006 Sep;126(9):1948-65. The presence of an autocrine adrenergic and cholinergic intra/intercellular signal transduction network in the human epidermis...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 08

A Critical Appraisal of Vitiligo Etiologic Theories. Is Melanocyte Loss a Melanocytorrhagy?

YVON GAUTHIER1, MURIEL CARIO ANDRE2 and ALAIN TAIЁEB1,2

1Service de Dermatologie, Hoˆpital St Andreґ, CHU de Bordeaux ceґdex, France; 2Inserm E 0217, Universiteґ V Segalen Bordeaux, 146 rue Leґo Saignat, Bordeaux ceґdex,...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 02

The haptenation theory of vitiligo and melanoma rejection: a close-up.

Westerhof W, Manini P, Napolitano A, d'Ischia M.

Exp Dermatol. 2011 Feb;20(2):92-6. doi: 10.1111/j.1600-0625.2010.01200.x. Source Color Foundation, Landsmeer, the Netherlands. wietewesterhof@colorfoundation.org Erratum...

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Posted to Library  / Immunology, Psycho-social aspects, Dermatology news 2011, Treatment variables, Guidlines and Reviews, Biochemistry, Children, Cosmetic Surgery, Genetics, Laser Therapy, Melanogenesis Sep 02

Role of interleukin-17 in the pathogenesis of vitiligo.

Bassiouny DA, Shaker O.

Clin Exp Dermatol. 2011 Apr;36(3):292-7. doi: 10.1111/j.1365-2230.2010.03972.x. Epub 2010 Dec 24. Source Department of Dermatology, Kasr El-Aini University Hospital, Cairo...

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Symposium videos

Videos from Vitiligo World Symposium

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Become a contributor

The non-profit VR Foundation accepts a variety of contributed material on vitiligo, melanoma and pigmentary disorders for possible inclusion on the website www.Vitinomics.net.

More...

25 JUNE INITIATIVE

The 25June Initiative aims to increase awareness of vitiligo and raise funds for research, national vitiligo associations and support groups. Led by the VR Foundation, this year’s goal is to mark World Vitiligo Day on June 25 a date to be observed annually by the United Nations.

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